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Enorma Post Natal Mental Wellness

1121.002940.00

  • Post Natal Depression is associated with symptoms such as Sleep Disorders, Anxiety, Sexual Problems, Stress, and Depression faced by Post Natal Mothers.

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Description

Why Enorma Post Natal Mental Wellness?
Our product contains, Ashwagandha Extract (5% Withanolides) and Green Tea Extract (Theanine), which helps to Overcome Stress, Tulsi (Ursolic acid) helps to Overcome Sleep Disorders and Sexual Problems, Iron and Tulsi (Ursolic acid) helps to Overcome Anxiety and Depression is overcome by Curcumin, Green tea extract (Theanine), Blackseed Oil (Thymoquinone), Zinc and Iron.

Basis Esperer Nutrition proprietary research on DINI Axis (DIET-INFECTION- NUTRITION- IMMUNITY) outcome which addresses the association between diet and an infectious risk factor for lifestyle chronic disease. DINI confirms Therapeutic Nutritional Interventions through Immunomodulatory Pathways to improve patient’s quality of life. DINI Axis is carefully integrated into Esperer Nutrition portfolio which prevents and manages the disease better.

Nutritional Information

Rational

EON’s nutritional product enriched with major ingredients such as Ashwagandha Extract (5% Withaniolide), Tulsi (Ursolic acid), Black seed oil (Thymoquinone), Green tea extract (Epigallocatechin-3-Gallate) and Curcumin for treatment of Post-Partum Depression.(PPD)

Introduction:

Postpartum depression (PPD) is a complex mix of physical, emotional, and behavioural changes that happen in some women after giving birth. Postpartum depression is linked to chemical, social, and psychological changes that happen when having a baby. The term describes a range of physical and emotional changes that many new mothers experience. PPD can be treated with medication and counselling.

Problems associated with PPD: The symptoms which occurs due to PPD are:

  • Sleep disorders – Sleep disorders are very common in patients suffering from PPD.
  • Anxiety- PPD leads to anxiety problems in patients.
  • Sexual problems – PPD may lead to sexual disorders in patients.
  • Stress and depression – These symptoms signify that the patient, is having PPD.

To overcome the symptoms of PPD, Eon’s product contains major ingredients such as as Ashwagandha Extract (5% Withaniolide), Tulsi (Ursolic acid), Black seed oil (Thymoquinone), Green tea extract (Epigallocatechin-3-Gallate) and Curcumin.

  • Ashwagandha Extract (5% Withaniolide) – Ashwagandha can restore the physical and mental strength of the body. Ashwagandha is an adaptogen, meaning it helps the body to adapt to physical, biological, and chemical stress. Ashwagandha is a vital therapeutic herb for post pantrum depression (PPD) support as it helps in eases stress and depression. Extract of W. somnifera (withaniolide) significantly increases the cell mediated immunity (CMI) in normal mice. Root extract enhances the level of interferon gamma (IFN-γ), interlukin-2 (IL-2) and granulocyte macrophage colony stimulating factor (GM-CSF) in mice, suggestive of an immunopotentiating and myeloprotective effect. Ashwagandha extract enhances nitric oxide synthatase activity of the macrophages, which in turn increases the microbial killing power of these immune cells. It activates and mobilizes macrophages for rendering increased phagocytic activity, potentiates activity of lysosomal enzymes and acts as an anti-stress molecule and anti-inflammatory agent in mice and rat. Immune enhancement with ahswagandha extract has also been observed in mice with myelosuppression induced by cyclophosphamide, azathioprin and prednisolone. Root extract of W. somnifera has been reported to induce helper T-lymphocyte (Th1) polarised cell mediated immune response in BALB/c mice. Both immunostimulatory and immunosuppressive properties are present in ashwagandha extract. It induces inhibition of delayed hypersensitivities. Powdered root extract from ashwagandha has profound effect on production of healthy white blood cells thereby it is an effective immunoregulator as well as chemoprotective agent in mice. It has been found that the nitric oxide activities of the macrophages are enhanced by W. somnifera via induction of nitric oxide synthase enzyme activity. The plant is also responsible to cause down regulation of the senescence-specific beta-galactosidase activity.
  • Tulsi (Ursolic acid) – Holy basil fights depression by lowering the creation of cortisol in the body. Cortisol is a stress hormone, and its high levels of cortisol are bad for health since it causes depression, fatigue, weight gain, problems with sleep, sexual problems, and anxiety. Holy basil lowers cortisol levels, and this helps to improve mental clarity and memory. The herb also acts on dopamine and serotonin, helps to balance the two hormones to improve mood and with improved mood comes a calming effect on the mind and soul. INF-ɣ is known to be secreted during infection due to intracellular pathogens and has potentially antiviral, INF-ɣ acts as one of the inhibitors of Th2 type response due to IL-4, and IL-4 secretion in turn limits over activation of Th1 by inhibiting the actions of INF-ɣ . Although levels of IL-4 were increased significantly by the use of tulsi extract, the increase was not so high as compared to the increase in the levels of INF-ɣ. This indicates that in tulsi extract, there was initial polarization of Th1 type of response (INF-ɣ) followed by Th2 type (IL-4). Thus, it can be inferred that when immune challenge was given in the form of phytohemagglutinin (PHA) and lipopolysaccharides (LPS) in the whole blood culture, tulsi extract had mounted an effective immune response of Th1 type (INF-ɣ). This increase in cytokine level is also supported by significant increase in the percentages of T-helper cells (CD3+CD4+) and NK-cells (CD16+CD56+), however, no significant changes were found in T-cytotoxic cells (CD3+CD4+) and B-cells (CD19+).
  • Black seed oil (Thymoquinone) – The long-term administration of Nigella sativa L. oil is highly useful in coping with stress as it increases the availability of 5-HT at synaptic sites by increasing plasma and brain tryptophan concentrations, thus increasing 5-HT synthesis and may also potentiate monoamine functions by inhibiting the activity of degradative enzymes leading to antidepressant-like effects . Interleukin 12 (IL-12) is a substantial immunomodulatory cytokine which is manufactured by macrophages, dendritic cells and antigen presenting cells. The production of this cytokine during infection adjusts innate immune responses and determines the adaptive immune responses sequence to be elicited. Also, IL-12 can evoke the assembly of IF-γ from T helper type 1 (Th1), activated CD8 T cells and natural killer cells that in turn, aggravates macrophages to destroy intracellular organisms. IF-γ prompts the differentiation of CD4+ T cells into Th1 cells that further produces IF-γ again. Moreover, IL-12 provokes TNF-α production that possesses a pivotal role in scenario of immune regulation through monitoring lymphocyte proliferation, survival and apoptosis via paracrine/autocrine signals. The later function of TNF-α is concerned with maintenance of immune homeostasis and self-tolerance. The crosstalk between innate and adaptive immune system that is arbitrated by IL-12 and IF-γ, contributes a substantial role in infectious agent control. These results explained the cell mediated immunostimulatory effect of thymoquinone where IL-12 enhanced IF-γ that acted in autocrine and paracrine manner to increase CD8 cells activity. Both γ-IF and TNF-α could stimulate macrophages activity to eliminate infectious agent.
  • Green tea extract (Epigallocatechin-3-Gallate) – Theanine, one of the major amino acids contained in green tea, has a tranquilizing effect on the brain and it showed that the oral intake of theanine lowers the stress response in human Theanine is one of the major amino acid components in green tea and can pass through the blood-brain barrier . Dopamine and serotonin dysfunction is a credible etiological candidate for depressive symptoms and theanine increases the brain serotonin and dopamine concentrations which helps to reduce depression. In the innate immune system, in vitro Epigallocatechin-3-Gallate (EGCG) supplementation dose-dependently reduces neutrophil migration induced by chemokine IL-8 and neutrophil chemotaxis toward cytokine-induced neutrophil chemoattractant-1 The oral administration of green tea extract or EGCG is shown to inhibit neutrophil recruitment to the inflammation sites in several animal studies such as mouse model of inflammatory angiogenesis. Similarly, EGCG is also shown to inhibit monocyte migration by reducing secretion of the chemokine monocyte chemotactic protein-1 (MCP-1) and its receptor (CCR2) expression Monocytes/macrophages are the primary source for most of the prominent proinflammatory mediators. EGCG’s anti-inflammatory property is mainly drawn from its inhibitory effect on production of proinflammatory molecules in a variety of monocytes/macrophages cell type.
  • Curcumin – Potential mechanism of action of curcumin on depressive symptoms is related to the suppression of transcription signaling pathways of some nuclear factors, such as nuclear factor kappa B, which is essential for the production of pro-inflammatory cytokines (such as interleukin-6 and interleukin-1b) and is thus involved in the pathogenesis of inflammation. Finally, curcuminoids reduces the levels of circulating C-reactive protein, a biomarker of systemic inflammation and this helps in reducing depression. Curcumin increases the brain levels of serotonin, noradrenaline and dopamine by inhibiting the (monoamine oxidase) MAO enzyme. a combination of curcumin with other antidepressants has shown to synergistically increase the serotonin levels and enhance antidepressant like activity. Curcumin also increases hippocampal neurogenesis in chronically stressed rats via modulation of hypothalamic–pituitary–adrenal (HPA) axis and up regulation of 5-HT1A receptors and It inhibits the NF-kB activation pathways of innate immunity and thus prevents release of IFN-a and other cytokines. These cytokines lead to dysregulation of HPA axis, metabolism of monoamine neurotransmitters and neuronal plasticity. Thus, curcumin might be helpful in depression by interfering at an early stage in its pathogenesis. Indoleamine-pyrrole 2,3-dioxygenase (IDO) is an enzyme expressed in multiple cell types including macrophages, dendritic cells, astrocytes and microglia and is strongly activated by the pro-inflammatory cytokine IFN-γ and to a lesser extent TNF-α, IL-1 and IL-6. IDO can also be induced by lipopolysaccharides. IDO is important in depression as it reduces serotonin synthesis by catabolising tryptophan, the primary amino-acid precursor of serotonin, into kynurenine pathway metabolites.

References:

    1. Abbas, S.S. and Singh, N. (2006). Anti-stress Agents (Herbs) of Indian Origin – Herbal Drugs, A twenty first century perspective. Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization (DRDO), Govt. of India, Delhi, 578-591.
    2. Abbas, S.S., Bhalla, M. and Singh, N. (2005). A clinical study of Organic Ashwagandha in some cases of uterine tumors (fibroids) and dermatofibrosarcoma. Proc. workshop on essential medicines, adverse drug reactions and therapeutic drug monitoring. Scientific Convention Centre, Lucknow, 143-144.
    3. Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 2014; 4:177.
    4. Ven Murthy MR, Ranjekar PK, Ramassamy C, et al. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. Cent Nerv Syst Agents Med Chem 2010; 10:238–46.
    5. Kulkarni SK, Dhir A. Withania somnifera: an Indian ginseng. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32:1093–105.
    6. Mirjalili MH, Moyano E, Bonfill M, et al. Steroidal lactones from Withania somnifera, an ancient plant for novel medicine. Molecules 2009; 14:2373–93.
    7. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 2003; 289:3095–105.
    8. Trivedi MH, Rush AJ, Wisniewski SR, Nierenberg AA, Warden D, Ritz L, et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry 2006; 163:28–40.
    9. Abdipranoto A, Wu S, Stayte S, et al. (2008) The role of neurogenesis in neurodegenerative diseases and its implications for therapeutic development. CNS Neurol Disord Drug Targets 7: 187–210.
    10. Akhondzadeh S, Jafari S, Raisi F, et al. (2009) Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo-controlled trial. Depress Anxiety 26: 607–611.

    Eon’s product contains major ingredients such as as Ashwagandha Extract (5% Withaniolide), Tulsi (Ursolic acid), Black seed oil (Thymoquinone), Green tea extract (Epigallocatechin-3-Gallate) and Curcumin., along with other ingredients which helps to treat PPD. Below we present the formula of the product.

    Post-Partum Depression(capsules)  
    Each Capsule contains UNIT Qty
    Energy Kcal  
    Protein g  
    Carbohydrate g  
    Sugar (As Sucrose) g  
    Fat g  
    Curcumin mg 50
    Ashwagandha Extract mg 75
    Tulsi Extract mg 50
    Green tea Extract mg 50
    Zinc mg 10
    Iron mg 15
    Vitamin D2 IU 400
    Black seed oil mg 280
    DHA (Docohexaenoic acid) 40% mg 65

FAQ

1. What do you mean by Post Natal Depression or Post Partum Depression? Postpartum: The period just after delivery, as with postpartum depression. Postpartum refers to the mother, and Post Natal to the baby. This is a mood disorder that affects some women after pregnancy and childbirth. A woman who has just given birth may feel anxiety, deep sadness, and exhaustion afterwards. Symptoms can be so severe that they interfere with mother’s ability to carry out daily activities and care for themselves, their babies, and others. 2. Does Enorma Postnatal Mental Wellness have any side effects on Mother? Our products comprise the highest quality ingredients and are safe to consume when used as per the stated label. However, please consult a health practitioner if you have any prior medical conditions. 3. What is the best time of the day to take a tablet? Recommended Usage: “For Women” 1 Tablet once a day after a meal or as suggested by Healthcare Professional. 4. For how long do I need to use this product? Use the product in continuation for at least 8 Weeks for effective results or as suggested by your Healthcare Professional. 5. What is the research on this product? The product is developed by the research team who has profound experience in the world of nutrition. For more information, please visit the R&D innovation page on the website.

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