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Enorma Post Menopausal Health

600.00870.00

  • The time of a woman’s life following menopause is called Post Menopause.
  • During this time, many of the bothersome symptoms a woman may have experienced before Menopause gradually decrease.
  • But because of several factors, including a Lower Level of Oestrogen, Post Menopausal women are at increased risk for several health conditions, such as Osteoporosis and Heart Disease.
  • It is a Hormonal Disorder common among women of reproductive age.
  • Post Menopause causes Hot Flushes, Night Sweats, Irregular Period, Mood Swings, Headaches, Digestive Problems, Fatigue, Anxiety, Disturbed Sleep, Hair Loss, Memory Loss, Weight Gain and Osteoporosis.

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Description

Why Enorma Post-Menopausal?
Our product contains, Shatavari (Asparagus Racemosus) Extract, Ashok (Saraca Indica) Extract, Liquorice (Glycyrrhiza glabra) Extract, Jatamasi (Nardostachysjatamansi), Black Cohosh (Cimicifuga racemosa) Soya Isoflavone Extract and Vitamin E which Prevents Hot Flushes, Shatavari (Asparagus Racemosus) Extract, Jatamasi (Nardostachysjatamansi) and Black Cohosh (Cimicifuga racemosa) Reduces Night Sweats, Shatavari (Asparagus Racemosus) Extract Controls Irregular Periods, Soy Isoflavones Reduces Mood Swings, Caltrops (Tribulus Terrestris), Ashwagandha (Withaniasomnifera) Extract and Soy Isoflavones Reduces Fatigue, Caltrops (Tribulus Terrestris), Ashwagandha (Withaniasomnifera) Extract and Vitamin B3 Reduces Anxiety, Vitamin B3 helps to Control Disrupted Sleep, Hair Loss is prevented by Biotin, Vitamin B3 helps to Control Memory Loss, Green Tea extract helps to Control Weight Gain, Post Menopausal Headaches are controlled by Vitamin B3 and Osteoporosis is prevented by Citrus Bioflavonoids, Vitamin A, D, L-Glutamic Acid, Zinc and Copper.

Basis Esperer Nutrition proprietary research on DINI Axis (DIET-INFECTION- NUTRITION- IMMUNITY) outcome which addresses the association between diet and an infectious risk factor for lifestyle chronic disease. DINI confirms Therapeutic Nutritional Interventions through Immunomodulatory Pathways to improve patient’s quality of life. DINI Axis is carefully integrated into Esperer Nutrition portfolio which prevents and manages the disease better.

Nutritional Information

Rational

EON’s nutritional product enriched with major ingredients such as Shatavari (Asparagus racemosus) Extract, Ashoka (Saraca indica) Extract Arjuna (Terminalia arjuna), Liquorice (Glycyrrhiza glabra) Extract, Caltrops (Tribulus terrestris) Soya isoflavone Extract, Black cohosh (Cimicifuga racemosa) and Green tea Extract for treatment of Post-Menopausal symptoms.

Introduction:

Post menopause is the name given to the period of time after a woman has not bled for an entire year (the rest of your life after going through menopause). During this stage, menopausal symptoms, such as hot flashes, may ease for many women. The time of a woman’s life following menopause is called post menopause. During this time, many of the bothersome symptoms a woman may have experienced before menopause gradually decrease. But because of several factors, including a lower level of estrogen, postmenopausal women are at increased risk for a number of health conditions, such as osteoporosis and heart disease. Osteoporosis is a hormonal disorder common among women of reproductive age.

Problems associated with Post menopause: The symptoms which occurs due to post menopause are:

  • Hot flushes – One of the most common symptoms of menopause, hot flushes affect around 75% of menopausal women. Hot flushes normally appear as a rising redness on the chest, neck and face and can make feel very overheated and sweaty.
  • Night sweats -Essentially, night sweats are hot flushes that occur at night and can disrupt sleep or can lead to feeling unpleasant when waken up.
  • Irregular periods -Because menopause is all to do with the end of the reproductive years, the periods will start to dissipate as the hormone production decreases. These can, therefore, become very erratic.
  • Mood swings -With studies showing that mood swings affect 27% of menopausal women, this can feel like a more extreme version of the mood swings that may have experienced during the periods.
  • Headaches -These are typically more common for women who experienced them during their periods.
  • Fatigue- One of the more common symptoms of menopause, many women will notice a feeling of extreme tiredness.
  • Anxiety -Along with mood swings, menopausal women may notice increased feelings of anxiety. As many as one in three women may experience this during menopause.
  • Disrupted sleep -Because of all the changes going on in the body (as well as the other menopausal symptoms), might experience disrupted sleep and insomnia.
  • Hair loss- While most people are aware that a lot of men lose their hair as they get older, not everyone realises that women get this too. Menopause can act as an accelerator for hair loss, leaving it looking thinner.
  • Memory lapses – These are usually only temporary, but memory lapses can occur during menopause.
  • Weight gain – Many women notice weight gain when they start taking the contraceptive pill, caused by a major change in hormones. The major change in hormones during menopause can also cause weight gain but this can usually be combated by healthy eating and exercising.
  • Osteoporosis – Bone density can drop by up to 20% after the menopause, which puts at risk of osteoporosis.

Eon’s product contains major ingredients such as Shatavari (Asparagus racemosus) Extract, Ashoka (Saraca indica) Extract, Arjuna (Terminalia arjuna), Liquorice (Glycyrrhiza glabra) Extract, Caltrops (Tribulus terrestris), Soya isoflavone Extract, Black cohosh (Cimicifuga racemosa) and Green tea Extract which helps to overcome the symptoms of post menopause.

  • Shatavari (Asparagus racemosus) Extract – Shatavari helps on relieving menopausal syndrome including hot flushes, irritability, vaginal dryness, night sweats etc.It increases the white blood count and almost stimulates macrophages which helps to combat candida and it helps to balance hormones & menstruation, enhance libido & fertility and reduce menopausal symptoms. Shatavari is also an adaptogen with a regulating effect throughout the body, helping to nourish a weakened and depleted system. Shatavari (Asparagus racemosus) being a known source of phytoestrogens can be effective in reducing adverse menopausal symptoms (The chemicals entities from plants which mimic hormones are called phytoestrogens). These are weaker than natural estrogens in action. However, they compete with estrogen for estrogen receptors. In the presence of excess of estrogens in the body phytoestrogens may have antiestrogenic effect by occupying some estrogen receptor. During menopause body experiences a withdrawal to estrogen, and phytoestrogens occupy vacant receptors and stimulate estrogenic action. Various formulas containing A. racemosus have shown their effectiveness in alleviating the symptoms in postmenopausal period and in hysterectomised patients. The immunomodulatory effect of Shatavari are as follows: They mainly focuses on the lymphocytes and cytokines, since T & B lymphocytes are the backbone of the immune system and modulation of Th1/Th2 immunity are important biological targets for immunostimulant. Upon oral administration of the compounds there has been significant and dose dependent increase of CD3 & CD19 count and Th1/Th2 cytokines. Results obtained were comparable to levamisole, indicating that the compounds were potent immune system stimulator. Steroidal saponins, shatavaroside A and shatavaroside B , isolated from the methanolic extract of A. racemosus, and their immunomodulatory activity have been evaluated using poly-morphonuclear leukocyte function test and some more sensitive assays such as nitroblue tetrazolium, nitrous oxide and chemiluminescence assays were used as a confirmatory test for the activity. The steroidal saponins isolated were found to be active at nano concentrations (5ng/mL) and can act as a potent immunostimulant.
  • Ashoka (Saraca indica) Extract – Ashoka extract helps in reducing problems associated with postmenopausal syndrome such as hot flashes and it is capable of bringing back the balance between estrogen and progesterone which recommended for the management of poly cystic ovarian disease (PCOD). Ashokarishta is one of the ayurvedic polyherbal-fermented liquid formulations known to cure gynecological disorders. It is considered as an ideal rejuvenator. Ashokarishta has good free radical scavenging, reducing power, and superoxide scavenging activity. The immunomodulatory response of ashokarishta extract shows that IL‑8 (Interleukin‑8), a potent vasodilator released by macrophages under stressful conditions. significantly increases in women with hot flashes and it suggests that macrophages sense the decline in estrogen and responded by secreting IL‑8. Working with cultured cells, researchers at the University of Buffalo found that ashokarishta extact decreases the genetic expression of IL‑8.
  • Arjuna (Terminalia arjuna)– Arjuna is a herb touted for its ability to augment heart functions, thus helping women preserve normal blood pressure and averting cardiac ailments and with a decrease in estrogen levels in the female body, the regulation of fat metabolism and control of cholesterol levels becomes a challenge. T. arjuna bark extract has strong beneficial effect on postmenopausal skin. Administration of T. arjuna bark extract significantly increases skin sebum content and skin blood microcirculation. Daily administration of T. arjuna bark extract revealed a significant reduction of skin sagging. T. arjuna bark extract has a comparable activity on cutaneous ageing without influencing hormone metabolism, as demonstrated in an oestrogen receptor- binding study.
  • Liquorice (Glycyrrhiza glabra)- Extract Licorice roots decreased the frequency and severity of hot flashes. The administration of this harmless, inexpensive herb well accepted by the menopausal women together with the appropriate and continuous physical activities and consumption of dairy products are recommended for relieving this complication. Licorice is an herb administered for relieving the effect of hot flashes in menopausal women. It is more famously called licorice and contains terpenes, saponins, flavonoids, isoflavonoids, and steroids. It has various levels of estrogenic activities, andit is more effective than hormone replacement therapy (HRT) in improving hot flash duration. The immunomodulatory response of liquorice demonstrated that the licorice (Glycyrrhiza uralensis Fisch) polysaccharide has immunomodulatory effects evident through the activation of CD4+ and CD8+ immune cell populations and increased production of various cytokines, such as IL-2, IL-6, and IL-7.
  • Caltrops (Tribulus terrestris)- Tribulus is a plant that produces fruit covered with spines.Tribulus has chemicals that might increase levels of some hormones and it improves some menopausal symptoms such as depression and tiredness .The effect of tribulus alone on menopausal symptoms is unknown. Tribulus terrestris is a plant which showed a significant increase in erectile function after the oral administration of the extract in treatment of sexual dysfunction in menopausal women. Products which are derived from Tribulus, can increase serum levels of endogenous testosterone. The main constituents of T. terrestris are steroids, saponins, flavonoids, and alkaloids. The hydrolyzed saponins are transformed into steroidal sapogenins, with antispasmodic and natriuretic properties, and increase the production of luteinizing hormone (LH), testosterone, estrogen, and other steroids.
  • Soya isoflavone Extract – The beneficial effect of soy isoflavones on menopausal mood symptoms and fatigue and with increasing age and menopausal status, the frequency and severity of hot flashes decreased. soflavones, compounds abundant in soybeans, are thought to be responsible for exerting estrogen-like effects, thereby relieving menopausal symptoms. There are two types of estrogen receptors: ERα, the predominant form in the breast and uterus, and ERβ the predominant form in the cardiovascular system, urogenital tract, and bone. Isoflavones bind weakly to ERα, while the affinity of isofolavones to ERβ is higher. However, isoflavones can circulate at 10,000 times the concentration of estradiol and achieve greater binding potential. The immunomodulatory responses of Soya isoflavone extract states that saponins with triterpenoid nuclei, like those found in soybean plants, have alpha and beta ester groups that complex with cysteine residues on transcription factor NF-κB, rendering this transcription factor non-functional and thereby dampening the pro-inflammatory response and reducing the release of reactive oxygen species. These were corroborated in an experiment evaluating the effect of soy saponins on responses of peritoneal macrophages stimulated with LPS in vitro where soy saponins inhibited the release of PGE, NO, TNF-α, and monocyte chemotactic protein-1 (MCP-1) in a dose-dependent manner (range from 30 to 100 µg/mL) without affecting cell viability. Researchers concluded the reduced inflammatory response occurred via suppression of NF-κB activation by sequestering this transcription factor in the cytosol and preventing nuclear translocation.
  • Black cohosh (Cimicifuga racemosa)- It helps in reduction in night sweats and hot flashes. Black cohosh extract (BCE), a herbal preparation having the desired estrogen-like effects on the vaginal mucosa. BCE helps in decreasing luteinizing hormone (LH) in menopausal women. The immunomodulatory responses of black cohosh explains that splenic natural killer (NK) cell numbers were significantly decreased at all BCE doses, with the exception of absolute NK numbers at the 125 mg/kg dose. No effects were observed on T-dependent antibody responses of the humoral immune system, including the antibody-forming cell response to sheep erythrocytes (sRBC) and IgM antibody levels to both sRBC and keyhole limpet hemocyanin. Cytotoxic T cell (CTL) activity was increased, as the mixed leukocyte response. Anti-CD3 mediated proliferation and the delayed-type hypersensitivity response were unaffected. No effects were observed on innate immunity or on bone marrow cellularity and colony-forming units. Overall, BCE exposure in B6C3F1/N mice for 28 days at doses up to 1000 mg/kg had minimal immune effects, with the exception of an increased CTL response.
  • Green tea Extract- Green tea extract is cost-effective herb to decrease lipid profile in postmenopausal women. Green tea extract is effective to decrease lipid profile in postmenopausal women without major side effects. The results showed that green tea could decrease the level of low-density lipoproteins (LDL), total cholesterol, and triglyceride significantly after intervention. The possible mechanism for lipid lowering of green tea may be since green tea or catechins may inhibit the diet lipid absorption. The immunomodulatory responses of green tea extract have been reported that in vitro extract supplementation, dose-dependently reduces neutrophil migration, induced by chemokine interleukin (IL)-8 with cytokine-induced neutrophil chemoattractant-1 at a dose of 15 mg ml or higher.
Clinical Trial ID Description Duration Indication Sponsor/ Agency
NCT00235924 To study and assess the effects on endometrium and breast of isoflavone in post-menopausal women. (Phase 3) 2004-2005 Post-menopause Laboratoires Arkopharma
NCT01116310 To study and to evaluate the efficacy of FITOGYN vs. placebo on the vasomotor symptomatology associated with menopause and to evaluate the symptoms of anxiety, the metabolic parameters in menopause and also to evaluate the quality of life associated to the vasomotor symptoms of menopause. (Phase 4) 2010-2012 Postmenopausal women with moderate vasomotor symptoms Laboratorios Casen-Fleet S.L.U.
NCT00010712 To study the effects of black cohosh on menopausal hot flashes. (Phase 2) 1999-2005 Post menopause National Center for Complementary and Integrative Health (NCCIH)
NCT03786809 To study the vascular effect of CIMICIFUGA RACEMOSA (CRDILA) on post-menopausal women. (Phase NA) 2016-2019 Postmenopausal Symptoms Federal University of Minas Gerais

References:

    1. Gogte VM. Ayurvedic Pharmacology and Therapeutic uses of Medicinal Plants Dravyagunavignyan. SPARC, Mumbai; 2000.
    2. Frawley D. Ayurvedic Healing – A Comprehensive Guide. Motilal Banarsidass Publishers Private Limited, Delhi; 1997.
    3. Sharma RK, Dash B. Charaka Samhita – Text with English Translation and Critical Exposition Based on Chakrapani Datta’s Ayurveda Dipika. Chowkhamba; Varanasi, India; 2003.
    4. Kirtikar, Basu. Indian medicinal plants. Dehradun, India: Bishen Singh Mahendra Pal Singh 1985.
    5. Bopana N and Saxena S: Asparagus racemosus—Ethnopharmacological evaluation and conservation needs. J Ethnopharmacol 2007; 110:1-15.
    6. Menopause. Howkins and Bourne Shaw’s A Textbook of Gynecology. Reprinted ed.: Elsevier; 2005. p. 56‑67.
    7. Cobin RH, Futterweit W, Ginzburg SB, et al. for the AACE Menopausen Guidelines Revision Task Force: American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of menopause. Endocr Pract 2006;12 (3):317.
    8. Speroff L and Fritz MA. Clinical Gynecologic Endocrinology and Infertility. 7th ed., Lippincott Williams and Wilkins, New York. (2005) 621-688.
    9. Berek JS. Novak›s Gynecology. 14th ed., Lippincott Williams and Wilkins, Philadelphia. (2007) 991-1137.
    10. Carpenter J. The hot flash related daily interference scale. J. Pain Manage.       (2001) 22: 979-989.

Our approach: Eon’s product contains major ingredients such Eon’s product contains major ingredients such as Shatavari (Asparagus racemosus) Extract, Ashoka (Saraca indica) Extract, Arjuna (Terminalia arjuna), Liquorice (Glycyrrhiza glabra) Extract, Caltrops (Tribulus terrestris), Soya isoflavone Extract, Black cohosh (Cimicifuga racemosa) and Green tea Extract, along with other ingredients which helps to treat post menopause and its associated symptoms. Below we present the formula of the product.

Formula:

Serving Size: 1 Tablet UNIT   Specification
Energy Kcal TBD
Protein g TBD
Fat g TBD
Carbohydrate g TBD
Sugar (Sucrose) g TBD
Shatavari (Asparagus racemosus) Extract mg 65 Standardized Extract
Ashok (Saraca indica) Extract mg 65 Standardized Extract
Arjuna (Terminalia arjuna) mg 50 Standardized Extract
Liquorice (Glycyrrhiza glabra) Extract mg 35 Standardized Extract
Caltrops (Tribulus terrestris) mg 50 Standardized Extract
Indian pennywort (Centella asiatica Extract mg 35 Standardized Extract
Jatamasi (Nardostachys jatamansi) mg 25 Standardized Extract
Ashwagandha (Withania somnifera) Extract mg 50 5% Withaniolide
Soya isoflavone Extract mg 40 40%
Black cohosh (Cimicifuga racemosa) mg 45 2.5% Triterpene glycosides
Citrus bioflavonoid mg 35 Available Source
Green tea Extract mg 50 (EGCG, L-Theanine)
Vitamin A mcg 600 Available Source
Vitamin D IU 400 Available Source
Vitamin E mg 10 Available Source
Vitamin B3 mg 15 Available Source
Vitamin B6 mg 1.8 Available Source
Vitamin B12 mcg 1 Available Source
Folic acid mcg 180 Available Source
Biotin mcg 30 Available Source
Vitamin C mg 35 Available Source
L-Glutamic acid mg 15 Available Source
L-Lysine mg 15 Available Source
Iron mg 20 Available Source
Zinc mg 10 Zinc monomethionine
Iodine mcg 100 Available Source
Selenium mcg 25 Available Source
Copper mg 1.5 Available Source
Manganese mg 2.0 Available Source
Chromium mcg 35 Available Source
Molybdenum mcg 35 Available Source

FAQ

1. What do you mean by Postmenopause?
Post Menopause: This is the name given to the period after a woman has not bled for an entire year (the rest of your life after going through menopause).

2. Does Enorma Post-Menopausal have any side effects?
Our products comprise the highest quality ingredients and are safe to consume when used as per the stated label. However, please consult a health practitioner if you have any prior medical conditions.

3. What is the best time of the day to take a Post Menopausal Health tablet?
Recommended Usage: “For Women” 1 Tablet once a day after a meal or as suggested by Healthcare Professional.

4. For how long do I need to use this product?
Use the product in continuation for at least 8 Weeks for effective results or as suggested by your Healthcare Professional.

5. What is the research on this product?
The product is developed by a research team that has profound experience in the world of nutrition. For more information, please visit the R&D innovation page on the website

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