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Enorma PCOS

1073.001988.00

  • Enorma PCOS for better Hormonal Health & Cycle Balance.
  • Our product contains Ashwagandha Extract which helps in the Management of Stress faced by PCOS patients, Amla Extracts to Prevent Irregular Period.
  • Zinc Prevents Unwanted Hair Growth and Acne and MCT oil helps in the Body Weight Management and Balance Blood Sugar Control.

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Description

Why Enorma PCOS Health?
Our product contains Ashwagandha Extract which helps in the Management of Stress faced by PCOS patients, Amla Extracts to Prevent Irregular Period. Many Vitamins and Micronutrients are used also. Among them, Vitamin C plays an important role in Scavenging ROS for Cellular Protection, Vitamin D2 helps to Improve Fertility and Mitigates Metabolic Risk Factors, Iron aids in Oxygen transport in the body, Zinc Prevents Unwanted Hair Growth and Acne and MCT oil helps in the Body Weight Management and Balance Blood Sugar Control.

Basis Esperer Nutrition proprietary research on DINI Axis (DIET-INFECTION- NUTRITION- IMMUNITY) outcome which addresses the association between diet and an infectious risk factor for lifestyle chronic disease. DINI confirms Therapeutic Nutritional Interventions through Immunomodulatory Pathways to improve patient’s quality of life. DINI Axis is carefully integrated into Esperer Nutrition portfolio which prevents and manages the disease better.

Nutritional Information

Rational

EON’s nutritional product enriched with major ingredients such as Amla Extract (40% Tannins), Ashwagandha Extract (5% Withaniolide), Zinc and Iron for treatment of PCOS.

Introduction:

Polycystic ovary syndrome (PCOS) is a condition that affects a woman’s hormone levels. Women with PCOS produce higher-than-normal amounts of male hormones. Birth control pills and diabetes drugs can help fix the hormone imbalance and improve symptoms. Polycystic ovary syndrome (PCOS) is a hormonal disorder common among women of reproductive age. Women with PCOS may have infrequent or prolonged menstrual periods or excess male hormone (androgen) levels. The ovaries may develop numerous small collections of fluid (follicles) and fail to regularly release eggs. Women with PCOS produce higher-than-normal amounts of male hormones. This hormone imbalance causes them to skip menstrual periods and makes it harder for them to get pregnant. PCOS also causes hair growth on the face and body, and baldness. And it can contribute to long-term health problems like diabetes and heart disease.

Problems associated with PCOS: The symptoms which occurs due to PCOS are:

  • Irregular periods- Infrequent, irregular, or prolonged menstrual cycles are the most common sign of PCOS. For example, you might have fewer than nine periods a year, more than 35 days between periods and abnormally heavy periods.
  • Heavy bleeding-The uterine lining builds up for a longer period, so the periods you do get can be heavier than normal.
  • Hair Growth- More than 70% of women with this condition grow hair on their face and body — including on their back, belly, and chest. Excess hair growth is called hirsutism.
  • Acne-Male hormones can make the skin oilier than usual and cause breakouts on areas like the face, chest, and upper back.
  • Weight Gain- Up to 80% of women with PCOS are overweight or obese.
  • Male-pattern Baldness – Hair on the scalp gets thinner and fall out.
  • Darkening of the Skin- Dark patches of skin can form in body creases like those on the neck, in the groin and under the breasts.
  • Headaches- Hormone changes can trigger headaches in some women.

To overcome the symptoms of PCOS, Eon’s product contains major ingredients such as Amla Extract (40% Tannins), Ashwagandha Extract (5% Withaniolide), Zinc and Iron

  • Amla Extract (40% Tannins)- Amla helps in improving fertility in women. It flushes out toxins, regulates menstrual cycle and causes hormonal balance. It also fights against the negative effects of PCOS like obesity, unwanted hair growth etc. Amla extract possesses antiapoptotic property and ceases DNA fragmentation, thus countering the immunosuppressive effect of Cr (VI) on lymphocyte proliferation. Further, it considerably restores IL‑2 and IFN‑γ production. This helped in restoring antioxidant status against Cr (VI) induced free radical production back to control level. This was concluded because of significant increase in WBC count and % lymphocyte distribution in E. officinalis‑treated mice, suggesting its ability to stimulate haemolymphopoetic system. The extract caused significant increase in migration area as well as nitro blue tetrazolium (NBT) reduction of peritoneal macrophages in E. officinalis‑treated mice. E. officinalis has been reported to inhibit chromium induced free radical production, and it restored the antioxidant status back to control level. It also inhibited the apoptosis and DNA fragmentation induced by chromium. It relieved the immunosuppressive effect of chromium on lymphocyte proliferation, and even restored the IL-2 and gamma-IFN production.
  • Ashwagandha Extract (5% Withaniolide)- Aswagandha extract balances the level of cortisol, which could improve stress and symptoms of PCOS. It also helps to balance hormone levels and thyroid function, support adrenal function, normalizes cortisol levels and maintain insulin levels in the body. Extract of W. somnifera (withaniolide) significantly increases the cell mediated immunity (CMI) in normal mice. Root extract enhances the level of interferon gamma (IFN-γ), interlukin-2 (IL-2) and granulocyte macrophage colony stimulating factor (GM-CSF) in mice, suggestive of an immunopotentiating and myeloprotective effect. Ashwagandha extract enhances nitric oxide synthatase activity of the macrophages, which in turn increases the microbial killing power of these immune cells. It activates and mobilizes macrophages for rendering increased phagocytic activity, potentiates activity of lysosomal enzymes and acts as an anti-stress molecule and anti-inflammatory agent in mice and rat. Immune enhancement with ahswagandha extract has also been observed in mice with myelosuppression induced by cyclophosphamide, azathioprin and prednisolone. Root extract of W. somnifera has been reported to induce helper T-lymphocyte (Th1) polarised cell mediated immune response in BALB/c mice. Both immunostimulatory and immunosuppressive properties are present in ashwagandha extract. It induces inhibition of delayed hypersensitivities. Powdered root extract from ashwagandha has profound effect on production of healthy white blood cells thereby it is an effective immunoregulator as well as chemoprotective agent in mice. It has been found that the nitric oxide activities of the macrophages are enhanced by W. somnifera via induction of nitric oxide synthase enzyme activity. The plant is also responsible to cause down regulation of the senescence-specific beta-galactosidase activity.
  • Zinc – Zinc has many benefits for women with PCOS including maintaining blood sugar balance, optimizing hormone production and decreasing PCOS symptoms, like unwanted hair growth or acne. Zn2+ decreases the production of TNF-α, increases the production of IL-10 but has no effect on the expression of IL-6. Hydrophilicity stimulates the release of pro inflammatory cytokines and chemokines. The microenvironment including microstructures and released ions developed by the MHTZn coating thus facilitates the polarization of macrophages and increases the secretion of both pro-inflammatory cytokines and anti-inflammatory cytokines. Cell proliferation in the micro-arc oxidation (MAO) and MHTZn conditioned media showed no significant difference. However, cells cultured in the MHTZn conditioned media display enhanced osteogenic activity, including increase in alkaline phosphatase assay (ALP) activity and mineralization. These behaviours are likely supposed to be regulated by inflammatory cytokines in the conditioned media secreted by the macrophages. TNF-α is found to ALP activity and mineralization in a dose-dependent manner by activating the NF-kB signalling pathway. IL-6, which is produced by osteoblasts, not only by macrophages, is known to slightly inhibit ALP and collagen synthesis in MC3T3-El cells. Furthermore, IL-6 can regulate the differentiation of both osteoclasts and osteoblasts and promote angiogenesis by stimulating the secretion of vascular endothelial growth factor (VEGF). TNF-α enhances the growth of human osteoblasts while IL-6 has no effects on osteoblast proliferation.
  • Iron – Iron helps to maintain insulin level in PCOS. The polycystic ovary syndrome (PCOS) is associated with insulin resistance and abnormal glucose tolerance. Iron overload may lead also to insulin resistance and diabetes. Serum ferritin levels are increased in PCOS, especially when glucose tolerance is abnormal, suggesting mild iron overload. Factors contributing to potential iron overload in PCOS include the iron sparing effect of chronic menstrual dysfunction, insulin resistance, and a decrease in hepcidin leading to increased iron absorption. Enhancement of erythropoiesis by androgen excess is unlikely, because soluble transferrin receptor levels are not increased in PCOS. Iron chelators such as desferrioxamine inhibit the activity of phagocyte oxidase and reduce reactive oxygen intermediate-dependent killing of bacterial pathogens, both in vitro and in vivo. iron chelation increases, and iron inhibits, expression of another important anti-microbial molecule, inducible nitric oxide synthase (iNOS), effects that are likely to be mediated by iron-dependent changes in transcription of the iNOS gene. Iron has also been shown to influence the activation of NF-κB, a transcription factor that is required for the expression of a number of genes involved in innate immunity and inflammation. Elevated intracellular iron promotes the activation of NF- κB, in part by increasing the production of reactive oxygen intermediates, while reduced intracellular iron inhibits the phosphorylation of the RelA sub-unit of NF-κB that is required for its activity. Another iron regulated transcription factor that has been shown to play an important role in innate immune responses, particularly the expression of inflammatory cytokines and anti-microbial peptides by macrophages, is HIF-1α. Under basal conditions, HIF-1α is prolyl hydroxylated by the action of an iron- and oxygen-dependent prolyl hydroxylase and thereby targeted for degradation by the proteasome. When intracellular iron concentrations are low, prolyl hydroxylation of HIF-1α is reduced and the protein is spared from degradation. Thus, in contrast to the effects on NF- κB, low intracellular iron promotes HIF-1α-dependent gene expression by preventing the degradation of the transcription.
Clinical Trial ID Description Duration Indication Sponsor/ Agency
NCT01600833 To study the association of ferrtin and homocysteine etc with RI and MS in polycystic ovary syndrome (PCOS). (Phase NA) 2012-2013 Polycystic Ovary Syndrome Taipei Medical University WanFang Hospital
NCT02460445 To study the effects of the decrease in iron tissue depots after scheduled bloodletting on insulin sensitivity, carbohydrate metabolism, classic and non-classic cardiovascular risk factors in patients with functional hyperandrogenism (polycystic ovary syndrome & idiopathic hyperandrogenism) on standard treatment with combined oral contraceptives (COC) according to usual clinical practice. (Phase NA) 2015-2020 Hyperandrogenism Manuel Luque Ramírez

References:

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    2. Flora SJS: Arsenic-induced oxidative stress and its reversibility. Free Rad Biol Med 2011, 51:257–281.
    3. Chaineau E, Binet S, Pol D, Chatellier G, Meininger V: Embryotoxic effects of sodium arsenite and sodium arsenate on mouse embryos in culture. Teratology 1990, 41:105–112.
    4. A. Farouk, A. K. Bashir, and A. K. M. Salih, “Antimicrobial activity of certain Sudanese plants used in folkloric medicine. Screening for antibacterial activity (I),” Fitoterapia, vol. 54, no.1, pp. 3–71, 1983.
    5. I. Ahmad, Z. Mehmood, and F. Mohammad, “Screening of some Indian medicinal plants for their antimicrobial properties,” Journal of Ethnopharmacology, vol. 62, no. 2, pp. 183–193, 1998.
    6. A.Ihantola-Vormisto, J. Summanen, H. Kankaanranta, H. Vuorela, Z. M. Asmawi, and E.Moilanen, “Anti-inflammatory activity of extracts from leaves of Phyllanthus emblica,” Planta Medica, vol. 63, no. 6, pp. 518–524, 1997.
    7. Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 2014; 4:177.
    8. A. S. Prasad, “Discovery of human zinc deficiency: 50 years later,” Journal of Trace Elements in Medicine and Biology, vol. 26, no. 2-3, pp. 66–69, 2012.
    9. C. Andreini, L. Banci, I. Bertini, and A. Rosato, “Counting the zinc-proteins encoded in the human genome,” Journal of Proteome Research, vol. 5, no. 1, pp. 196–201, 2006.
    10. Andrews NC. Forging a field: the golden age of iron biology. Blood. 2008; 112:219–230. [PubMed:18606887]

Our approach: Eon’s product contains major ingredients such Eon’s product contains major ingredients such as Amla Extract (40% Tannins), Ashwagandha Extract (5% Withaniolide), Zinc and Iron, along with other ingredients which helps to treat PCOS. Below we present the formula of the product.

Formula:

PCOS(basic)  
Each Capsule contains UNIT Qty
Energy Kcal  
Protein g  
Carbohydrate g  
Sugar (As Sucrose) g  
Fat g  
Amla Extract mg 75
Ashwagandha Extract mg 75
Vitamin C mg 40
Zinc mg 10
Iron mg 15
Vitamin D2 IU 400
MCT Oil mg 500

FAQ

1. What are the major benefits of Enorma PCOS?
Blood sugar control, bodyweight management, improves fertility, Mitigates Metabolic risk factor.

2. Does Enorma PCOS have any side effects?
Our products comprise the highest quality ingredients and are safe to consume when used as per the stated label. However, please consult a health practitioner if you have any prior medical conditions.

3. What is the best time of the day to take a PCOS tablet?
Minimum one tablet post afternoon meal is recommended dosage.

4. For how long do I need to use this product?
Use the product in continuation for at least 8 Weeks for effective results or as suggested by your Healthcare Professional.

5. What is the research on this product?
The product is developed by the research team who has profound experience in the world of nutrition. For more information, please visit the R&D innovation page on the website.

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